Systematic analysis of the experimental and clinical pharmacology of nicotinamide and prospects for the treatment of atherosclerosis

Nicotinamide (niacin) is a PP (Pellagra-Preventive) vitamer necessary for the synthesis of nicotinamide adenine dinucleotide (NAD). The NAD molecule coenzyme proteins involved in ATP from fats and carbohydrates. For more than 50 years, has been used as an antihyperlipidemic agent to improve blood microcirculation. results systematic analysis 70417 publications on pharmacology made it possible clarify molecular mechanisms vasoprotective action (including anti-inflammatory action), summarize experimental clinical studies anti-atherosclerotic effects treatment steatohepatosis counteraction obesity) cardioprotective properties nicotinamide. prospects combined use statins are shown, which allows reduce dosage statins.